DEPARTMENT FACULTY

  Jim Anthony
 
David Barondess
 
Ahnalee Brincks
  Gustavo de los Campos
 
Honglei Chen
 
Debra Furr-Holden
 
Joseph Gardiner
 
Hector M. González
 
Kelly Hirko
 
Claudia Holzman
 
Carol Janney
  Allan Kozlowski
 
Jean Kerver
 
Chenxi Li
 
Qing Lu
 
Zhehui Luo
 
Claire Margerison-Zilko
 
Janet Osuch
 
Nigel Paneth
 
Dorothy Pathak
 
James Pivarnik
 
Mat Reeves
 
A.Mahdi. Saeed
 
Nicole Talge
 
David Todem
 
Ana Vázquez
 
Elizabeth (Betsy) Wasilevich
 
Lixin Zhang
  Adjunct Faculty
  Emeritus Faculty

GRADUATE DIRECTOR

  David Barondess 

SPECIALISTS - RESEARCH

  Madeleine Lenski

 

Honglei Chen, MD, PhD

Professor of Epidemiology and Biostatistics

Department of Epidemiology and Biostatistics
909 Fee Road Room B601
East Lansing, MI  48824
517.353.8623
hchen@epi.msu.edu

Dr. Chen is a Professor at the Department of Epidemiology and Biostatistics of Michigan State University. His current research focuses on Parkinson's disease, which affects over 1 million older adults in the U.S. He works on several large prospective cohorts to ascertain the environmental and genetic causes of Parkinson's disease and to characterize high risk population through research on non-motor symptoms and biomarkers. The ultimate goal is disease prevention and more effective clinical management.

Dr. Chen's primary research interests include:

• Environments, Genes, and Gene-environment interactions in the etiology of Parkinson's disease: Genes and environmental factors, alone or in combination, contribute to the pathogenesis of Parkinson's disease. Over the past several years, his research has contributed to a better understanding of the role of environmental factors in Parkinson's etiology. For example, he reported that long duration of smoking, rather than smoking intensity, might underlie the lower risk of Parkinson's disease among smokers (Chen et al., Neurology 2010). He and collaborators also found that moderate to vigorous exercise (Xu et al., Neurology 2010), ibuprofen use (Chen et al., Annals Neurol 2005; Gao et al., Neurology 2011), and higher plasma urate (Chen et al., Am J Epidemiol 2009) were each associated with a lower risk of Parkinson's disease. In collaboration with an international consortium and others, he contributed to the identification of multiple genetic loci that affected the risk of late-onset Parkinson's disease (Simón-Sánchez et al., Nat Genet 2009; IPDGC, Lancet 2011) and the first gene-environment interaction that was identified in a genome-wide approach (Hemza et al., PLoS Genet 2011).

• Prodromal nonmotor symptoms in Parkinson's disease: Parkinson clinical diagnosis relies on the presence of motor dysfunctions, which do not become apparent until ~50% of the dopaminergic neurons have died. This may partially explain the failure of neuro-protection or disease modification trials for Parkinson's disease that all intervene after diagnosis. Over the past decade, it has become clear that Parkinson's patients also suffer from a variety of nonmotor symptoms, and some (e.g. smell loss, daytime sleepiness) may predate Parkinson's clinical motor onset. Dr. Chen's group therefore is working on characterizing these symptoms in older adults with the hope to identify a pre-diagnostic window where disease modification may be more realistic. He and collaborators have reported that low heart rate variability (Alonso et al, Ann Neurol, 2015), depression (Fang et al., Mov Disord 2010), daytime sleepiness (Gao et al., Am J Epidemiol 2011), constipation (Gao et al., Am J Epidemiol 2011), and erectile dysfunction (Gao et al., Am J Epidemiol 2007) were associated with future risk of Parkinson's disease mostly in a time dependent manner. In the future, Dr. Chen plans to evaluate more systematically nonmotor symptoms alone or in combination (Chen et al., Mov Disord, 2014; Liu et al., Neurology, 2015) in relation to Parkinson's diagnosis and how environment and genetic factors may alter the progression from preclinical to clinical Parkinson's disease.

Biography

Dr. Chen earned his M.D. from TianJin Medical University in TianJin, China, and Master's degree from the Chinese Academy of Preventive Medicine in Beijing, China. In 2001, he earned his Ph.D. in Nutritional Epidemiology from Tufts University in Boston, MA and then worked as a Research Fellow and Instructor at the Harvard School of Public Health. From 2005-2016, Dr. Chen worked at the Epidemiology Branch of the National Institute of Environmental Health Sciences and received his Tenured Senior Investigator appointment from NIH in 2013. He serves on the editorial board of the American Journal of Epidemiology and has over 130 original publications.

Selected Publications

Chen H, Jacobs E, Schwarzschild MA, McCullough ML, Calle EE, Thun MJ, Ascherio A. Nonsteroidal antiinflammatory drug use and the risk for Parkinson's disease. Ann Neurol. 2005;58(6):963-7. PMID: 16240369

Chen H, Huang X, Guo X, Mailman RB, Park Y, Kamel F, Umbach DM, Xu Q, Hollenbeck A, Schatzkin A, Blair A. Smoking duration, intensity, and risk of Parkinson disease. Neurology. 2010;74(11):878-84. PMID: 20220126; PMCID: PMC2836869.

Xu Q, Park Y, Huang X, Hollenbeck A, Blair A, Schatzkin A, Chen H. Physical activities and future risk of Parkinson disease. Neurology. 2010;75(4):341-8. PMID: 20660864; PMCID: PMC2918886.

Xu Q, Park Y, Huang X, Hollenbeck A, Blair A, Schatzkin A, Chen H. Diabetes and risk of Parkinson's disease. Diabetes Care. 2011;34(4):910-5. PMID: 21378214; PMCID: PMC3064050

Alonso A, Huang X, Mosley TH, Heiss G, Chen H: Heart rate variability and the incidence of Parkinson’s disease: the ARIC study: Ann Neurol doi: ;77(5):877-83. doi: 10.1002/ana.24393, 2015. PMID: 25707861 (NIEHS DIR paper of the month, and DIR paper of the year)
Liu R, Umbach D, Peddada S, Tröster AI, Huang X, Chen H: Potential sex differences in non-motor symptoms in early drug-naive Parkinson disease: Neurology (with editorial), 2015, PMID: 25925983 (NIEHS DIR paper of the month)

Fang F, Wirdefeldt K, Jacks A, Kamel F, Ye W, Chen H: CNS Infections, sepsis, and the risk for Parkinson’s disease. Int J Epidemiol. 41(4):1042-9. 2012; PMID: 22523201; PMCID: PMC3429872

Liu R, Young M, Chen JC, Kaufman J, Chen H: Ambient air pollution exposures and risk of Parkinson disease Environ Health Perspect. 2016 Jun 10. [Epub ahead of print] PMID: 27285422