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Jim Anthony
Gretchen Birbeck
Naomi Breslau
Hwan Chung
Wenjiang Fu
Joseph Gardiner
Claudia Holzman
Janet Osuch
Nigel Paneth
Dorothy Pathak
Jim Pivarnik
M. Hossein Rahbar
Phillip Reed
Mat Reeves
Mike Rip
A.M. Saeed
David Todem
Ellen Velie
Julie Wirth

 
 

Claudia Holzman, D.V.M., M.P.H., Ph.D.
Associate Professor of Epidemiology
Department of Epidemiology

Michigan State University
Department of Epidemiology
B601 West Fee Hall
East Lansing, Michigan 48824
Telephone: 517.353.8623  x122
Fax: 517.432.1130

E-mail:  holzman@msu.edu
Community of Science Expertise Profile

Research Interests

Claudia Holzman, Associate Professor of Epidemiology in the College of Human Medicine at Michigan State University, received her Doctor of Veterinary Medicine degree from Michigan State University in 1976, her Master’s of Public Health degree from University of Minnesota in 1986, and her PhD degree in epidemiology from University of Michigan in 1996. Dr. Holzman has been involved in reproductive and perinatal research, primarily focusing on the areas of  preterm delivery, brain injury in neonates, birth defects, and vaginal infections. In her earlier research, Dr. Holzman led the feasibility study that resulted in the establishment of a state-wide birth defects registry in Michigan.

Dr. Holzman currently has two ongoing studies, one on preterm birth (POUCH Study) funded by the National Institute of  Child Health and Development and the March of Dimes Birth Defects Foundation, and one on vaginal infections in non-pregnant women (DAISY Study) funded by the Blue Cross/Blue Shield of Michigan Foundation. The first study is a multi-community, prospective study designed to identify pathways to preterm delivery (e.g. infection, maternal vascular disease) by assessing psychosocial and biologic factors in approximately 2,000 pregnant women. Psychosocial antecedents in the preterm pathways are measured at the individual (participant interview) and ecological (community/ neighborhood conditions and resources) levels. Biologic markers and mediators are evaluated in maternal serum, plasma, vaginal fluid, urine, saliva, and hair collected in mid-trimester.  In addition, the study focus includes a detailed examination of  the delivered placenta, linking specific pathologic findings to various preterm delivery pathways. The second study, on vaginal infections, is a three-stage investigation of the epidemiology of  bacterial vaginosis (BV). The study began with a cross-sectional, quantitative  assessment of risk factors for BV in 498 women in the Greater Lansing Area, and has now progressed to the latter stages- qualitative research with small focus groups of women who have recurrent BV and/or who regularly use vaginal douches, and a small clinical trial to assess the effects of vaginal douching on changes in vaginal flora.

Selected Publications

Holzman C, Leventhal J, Qui H, Jones N, Wang J, BV Study Group. Factors linked to bacterial vaginosis in non-pregnant women (in press AJPH)

Holzman C, Bullen B, Fisher R, Paneth P, Reuss L, and the Prematurity Study Group. Pregnancy outcomes and community health: the POUCH Study of preterm delivery. (in press Paediatric and Perinatal Epidemiol.)

Wadland WC, Barry HC, Farquhar L, Holzman C, White A. Training medical students in evidence-based medicine: a community campus approach. Family Medicine 1999;31:703-8.

Holzman C, Jetton J, Fisher R, Senagore P, Mohan M, Paneth N.  Association of maternal IgM concentrations above the median at 15-19 weeks of gestation and early preterm delivery. Lancet 1999; 354;1095-6.

Holzman C, Paneth N, Fisher R, and the MSU prematurity group. Rethinking the concept of risk factors for preterm delivery: antecedents, markers, and mediators. Prenat Neonat Med 1998; 3: 47-52.

Courval JM, DeHoog JV, Holzman CB, Tay EM, Fischer L, Humphrey H, Paneth NS, Sweeney AM.  Fish consumption and other characteristics of reproductive-aged Michigan anglers--a potential population for studying the effects of consumption of Great Lakes fish on reproductive health.  Toxicology and Industrial Health 1996; 12: 347-359.    

Holzman C, Paneth N, Little R, Pinto-Martin J, NBH Study Team.  Perinatal brain injury in premature infants born to mothers using alcohol in pregnancy.  Pediatrics 1995; 95: 66-73.  (Selected for inclusion in the Year Book of Neonatal and Perinatal Medicine).

Pinto-Martin J, Riolo S, Cnaan A, Holzman C, Paneth N.  Cranial ultrasound prediction of disabling and non-disabling cerebral palsy in a low birth weight population.  Pediatrics 1995; 95:249-254.

Holzman C, Paneth N.  Maternal cocaine use during pregnancy and perinatal outcomes.  Epidemiologic Reviews 1994; 16: 315-334.

Holzman C, Paneth N.  Section authors in:  Robins LN, Mills JL, Krulewitch C.  Effects of exposure to street drugs in utero.  Am J Public Health 1993; 83: supplement.

Holzman C, Lin X, Senagore P, Chung H. Chorioamnionitis and Preterm Delivery. American Journal of Epidemiology. (in press).   (doi:10.1093/aje/kwm168).

Scheid JM,  Holzman C, Jones NM,  Friderici K, Nummy K, Symonds L, Sikorskii A, Regier M, Fisher R . Depressive Symptoms in Mid-pregnancy, Lifetime Stressors and the 5-HTTLPR Genotype.  Genes, Brain and Behavior. (in press). (doi: 10.1111/j.1601-183X.2006.00272.x).

Xue F, Holzman C, Rahbar MH, Trosko K, Fischer L. Maternal Fish Consumption, Mercury Levels, and Risk of Preterm Delivery. Environmental Health Perspectives 2007; 115 (1):42-7.

Messer L, Kaufman J, Laraia B, O’Campo P, Burke J, Eyster J, Holzman C, Culhane J, Elo I. The Development of a Standardized Neighborhood Deprivation Index: Associations with Adverse Birth Outcomes  Journal Of Urban Health; 2006; 83(6):1041-62.

Jones NM, Holzman C, Zanella A, Leece C, Rahbar MH ant he Prematurity Study Group. Assessing Mid-Trimester Salivary Cortisol Levels Across Three Consecutive Days in Pregnant Women Using an At-Home Collection Protocol. Paediatric and Perinatal Epidemiology; 2006; 20 (3):425-37. 

Holzman C, Eyster J, Tiedje LB, Roman LA, Seagull E, Rahbar, MH. A Life Course Perspective on Depressive Symptoms in Mid-Pregnancy. Maternal and Child Health J 2006; 10:127-138.

Holzman C, Leventhal J, Qui H, Jones N, Wang J, BV Study Group. Factors linked to bacterial vaginosis in non-pregnant women.  Am J Pub Health 2001;91:1664-70.

Holzman C, Bullen B, Fisher R, Paneth P, Reuss L, and the Prematurity Study Group. Pregnancy outcomes and community health: the POUCH Study of preterm delivery. Paediatric and Perinatal Epidemiology 2001:15 (suppl. 2) 136-158.

Holzman C, Jetton J, Siler-Khodr T, Fisher R, Rip T. Second trimester corticotropin-releasing hormone levels

     in relation to preterm delivery and ethnicity. Obstet Gynecol 2001; 97:657-63.