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The Department of Epidemiology and Biostatistics is located within the Michigan State University College of Human Medicine, a community-based medical school utilizing a network of practice sites and hospitals across Michigan.

The medical facilities of six Michigan communities are linked to the College. In addition, proximity to the Michigan Department of Community Health creates numerous opportunities for collaboration. These linkages provide practice sites for community epidemiologic investigations. Community-based research is supported by both an electronic infrastructure, which links all six campus sites, and a network of family practice groups that collaborate in research.

Listed below are some examples of research projects conducted by the faculty of The Department of Epidemiology and Biostatistics.

CURRENT RESEARCH

Airborne pollutants as triggers of Parkinson's Disease via the olfactory system

This is a multi-PI project supported by the US Department of Defense (9/2017-8/2022). Dr. Honglei Chen leads the epidemiology arm of this project. In this study, Dr. Chen and his team have objectively assessed the sense of smell of ~3,400 women, ages 50-79, recruited from the NIEHS Sister Study cohort. The primary goal of this project is to assess roles of air pollutants in olfactory impairment and their relevance to Parkinson’s disease.

CHARM Study

Prenatal Exposures and Child Health Outcomes: A Statewide Study (1 UG3 OD023285-01) is a collaboration among five Michigan institutions, and is one of 35 national pediatric cohorts funded under the aegis of the NIH-funded ECHO (Environmental Influences on Child Health Outcomes) program, a seven-year initiative that began in September 2016. All scientists affiliated with any of the five participating institutions in our state (Henry Ford Health System, the Michigan Department of Health and Human Services, Michigan State University, University of Michigan, and Wayne State University) are eligible to apply to either or both of two grants programs designed to support original research making use of the resources of this project.
www.charmstudy.org

CEEP

Conductive Education Evaluation Project (CEEP) was designed as a randomized clinical trial to compare the effectiveness of routine care for cerebral palsy (CP) with Conductive Education, an intensive, classroom-style CP therapy offered by the Conductive Learning Center (CLC) of Grand Rapids. The study enrolls children ages 2-6 for four week sessions. Signature characteristics of conductive education include specially trained conductors (teachers), daily sessions, rhythmic intention, peer motivation and specialized equipment. The study was first funded from 2007-2009 and received new funding from the State of Michigan in 2016 to restart the trial, enroll more families, and strengthen this research. PIs: Madeleine Lenski and Nigel Paneth. Research Coordinator: Deborah Weiland.

ELGAN-ECHO

Extremely Low Gestational Age Newborns (ELGAN-ECHO) began in the early 2000s as a large multi-regional NIH-funded study investigating antecedents of brain injury in newborns born under 28 weeks. Now in its third longitudinal phase, it continues as part of the nationwide NIH ECHO (Environmental Influences on Child Health Outcomes) initiative. In the first phase of the study, over 1,500 newborns and their parents were enrolled at 14 hospitals in the Lake Michigan area, New England, and North Carolina. Developmental assessments were obtained in infancy and for over 85% of children at corrected age of 24 months. The study was refunded to see children for neurodevelopmental follow-up around age 10. Currently in its third phase, now led by Dr Michael O’Shea at University of North Carolina, the cohort continues to be followed in their teen years to learn about long term outcomes of prematurity, environmental exposures, and their relationship to inflammatory and other perinatal biomarkers.
MSU site staff are Principal Investigators Madeleine Lenski and Nigel Paneth, and Research Coordinator Deborah Weiland.

MISTT

The Michigan Stroke Transitions Trial (MISTT) is a PCORI funded randomized clinical trial designed to help stroke patients and their caregivers after returning home from the hospital. Approximately three quarters of stroke survivors return home, but many face considerable physical, emotional, and financial challenges during the transition period. This 3-arm trial tested the efficacy of social work-led case management, or access to a curated patient-centered website, versus usual care. Outcome measures included QOL and the patient activation measure (PAM). A total of 265 stroke patients and 160 caregivers from 3 Michigan hospitals were enrolled in the trial. For further information contact Mat Reeves (PI) or Michele Fritz (Project manager).

Parkinson’s research in large population-based cohorts

Dr. Honglei Chen has collaborated to establish a Parkinson’s research component in several large prospective cohorts, including the NIH-AARP Diet and Health Study, the Atherosclerosis Risk In Communities Study (ARIC), and the Health ABC study, and the Shanghai Women’s Health Study. These studies have complementary cohort characteristics and share a common goal to dissect the natural history and etiology of Parkinson’s disease.  

Pesticides, Olfaction, and Neurodegeneration Among US Farmers (AHS-PASS)

This newly funded R01 project (2/2019 – 1/2024) aims to investigate roles of pesticides in olfaction impairment and their relevance to prodromal neurodegeneration. In Stage 1 of this study, Dr. Honglei Chen and co-investigators will objectively test the sense of smell of ~2,400 farmers from the Agricultural Health Study, and then, in Stage 2, conduct in-home clinical assessments for ~450 farmers to assess cognitive and motor symptoms.

Policy Change and Women’s Health

The goal of this NIH-funded study is to assess the impact of health and social policies, particularly Medicaid expansion under the Affordable Care Act, and health among women of reproductive age. We are using multiple national datasets to examine impacts of policies on preconception health, reproductive health behaviors, pregnancy health, and birth outcomes. The project is led by Dr. Claire Margerison.

POUCH Study

Etiologic Heterogeneity in Preterm Delivery
The aim of this study is to better understand the causes of preterm delivery by identifying the pathways through which risk of preterm delivery is mediated, and the role of maternal serum alpha fetoprotein in these pathways. Over seeing a Minority Supplement under this grant.  Claudia Holzman, PI

POUCHMoms

Jeanette Scheid PI, Co-PI Claudia Holzman, and Laura Symonds.

Research Training in Drug Dependence Epidemiology

Dr. James C. (Jim) Anthony serves as the director of our NIH/NIDA supported T32 and D43 research training fellowship programs based in the Department of Epidemiology within Michigan State University’s College of Human Medicine. Click here for more information  

PREVIOUS RESEARCH

CPON

Cerebral Palsy Outreach Network (CPON) is an internet resource for children with cerebral palsy (CP) and their families (see www.epi.msu.edu/cpon). The mission of CPON is to help families connect to needed services, provide scientific information about CP, and develop research on the causes and management of CP. CPON also helps sponsor a collaborative CP research in Michigan biennial conference. Nigel Paneth, PI.

Effect of Organochlorides on Male Infertility

This study investigated the relationship between measure of human male reproductive health, specifically semen quality and reproductive hormone levels, organochlorine compound environmental contaminants and polymorphisms in genes involved in contaminant and sex steroid metabolism Julie Wirth, PI Retired

Great Lakes Fisheater Study

Federally funded project assessing cognitive functioning in aging members of the Michigan Department of Community Health’s Lake Michigan Anglers cohort.
Joseph Gardiner, PI 

MASCOTS and MOSAIC Stroke Registries

The Michigan Acute Stroke Care Overview & Treatment Surveillance System (MASCOTS) was a pilot representative, statewide, hospital-based surveillance system of acute stroke care that collected data from over 2000 acute stroke cases treated in 16 Michigan hospitals during the 2002-2003 period. This pilot registry led to the development of MOSAIC – a statewide hospital based registry that is part of the National Paul Coverdell Acute Stroke Registry run by CDC. MOSAIC is also part of the American Heart Association’s Get-With-The Guidelines quality improvement registry which now includes almost 5 million observations. For further information contact Mat Reeves (PI).

OSSM

OSSM was inherited from Dr. Wilfried Karmaus. Its goal was to examine the association between organochlorine exposure and mRNA expression of sex steroid metabolites in female offspring of the original fisheater's project. Janet Osuch, PI, Retired  

OWL

OWL (Origins, Wellness, and Lifehistory in CP) was funded by NIH to study the etiology of cerebral palsy. Cases and controls were recruited at ages 2-15 through hospital and medical practices, researchers and physicians in three metropolitan areas - Ann Arbor, Lansing, and Grand Rapids. The study collected information on pregnancy and birth histories, services for children, and analyzed newborn blood spots routinely collected and stored for newborn screening in the State of Michigan, to learn about infection, inflammation, coagulation and thyroid disorders, and perinatal asphyxia as possible causes of CP. Site staff members are Principal Investigators Madeleine Lenski, MSPH and Nigel Paneth, MD, MPH and Research Assistant Deborah Weiland, MSN.

D43- ICHORTA

With this application, the directors and the faculty of a NIDA-supported T32 institutional research training program on drug dependence epidemiology seek to enhance the international research and research training capacities of the training program, NIH, NIDA and Fogarty International Center. This project will link faculty and students of the Bloomberg School of Public Health with the Universidad Peruana Cayetano Heredia in Lima, Peru. Jim Anthony, PI

Clusters of Drug Involvement in Chile (FIRCA)

This is a collaborative, epidemiological research project studying the earliest stages of youthful drug involvement, including coca paste and other cocaine use in Chile.
Jim Anthony, PI  

HRSA 

Multi-level analysis of disparities in Preterm Delivery

The purposes of the HRSA contract is to expand the use of multi-level modeling as a tool for examining the influences of neighborhood context on the risk of delivering prematurely, to disseminate examples of the analysis and develop strategies for instructing state and local maternal and child health (MCH) professionals on the value of contextual level variables and multi-level modeling, and help them to identify avenues for training in multi-level statistical techniques. Claudia Holzman, PI

K-Award: Drug Dependence

Drug Dependence Epidemiology and Enviromics

To combine enviromics, genetics, and epidemiology in research on drug dependence syndromes. Jim Anthony, PI

Perinatal Epidemiology Training Program

Trains pre and postdoctoral students in perinatal epidemiology.
Nigel Paneth, PI.

Polish Women Health Study

This international study looks at the “Effect of Changes in Diet and Other Factors on Breast Cancer Risk of Women Immigrants from Poland to the United States.”
Dorothy Pathak, PI

YWHHS

Young Women Health History Study  Breast cancer is the most common cancer in women younger than 50 years of age. Though we have some understanding of why some women develop breast cancer and others do not, we have a lot more to learn about breast cancer prevention. The goal of the Young Women’s Health History Study is to find ways to reduce the risk of breast cancer in young women.  Dorothy Pathak